Sled Dog Society of Wales
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    • Health & Wellbeing >
      • Health Conditions A - E >
        • Abnormal Heart Rhythm in Dogs
        • Alaskan Husky Encephalopathy (Sub acute Necrotizing Encephalomyelopathy)
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      • Dental Care
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      • Vaccinations, Worming, Microchipping >
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        • Microchipping
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        • Worming, Flea & Tick Prevention & Parasites
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    • Breeds >
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      • Wolf Hybrids >
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  • Equipment
    • Collars
    • Cooling Coats & Mats
    • Scooters, Dry Land Rig and Sleds
    • Walking Belt
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    • Stake out lines
  • Puppy and dog walking tips
  • Training
    • Canicross
    • Crate Training
    • Obedience training >
      • Bite Inhibition
      • Leave it Training
      • Recall Training
      • Sit Training
      • Sit & Stay Training
      • Walking to Heel Training
    • Temperature Guide to Safely Work Your Dog
    • Toilet Training
    • Vocal Commands
    • Weight Pull Training
    • Working In Racing Harness Sled/Dry Land Rig or Scooter
Picture
Alaskan Husky Encephalopathy (Sub acute Necrotizing Encephalomyelopathy)
 
Alaskan Husky encephalopathy is an inherited neurological disease affecting Alaskan Huskies.  Affected dogs are unable to produce a protein important in transporting the essential nutrient, thiamine (vitamin B1) into cells of the body and typically present with neurological symptoms between 6 months and 2 years of age. Cells of the nervous system are particularly dependent upon thiamine for the nutrient’s role in energy metabolism.  As seen in this disorder, severe thiamine deficiency leads to death of neurons in the brain and subsequent neurological disease.  Symptoms include weakness in limbs, altered mental state, loss of balance, abnormal gait, decreased facial pain sensitivity, difficulties eating or swallowing, seizures and blindness.  The progression of disease is variable with some dogs going through periods of static disease progression, but most dogs die due to disease complications or humane euthanasia within several months of initial clinical presentation.


Testing
Genetic testing of the SLC19A3 gene in Alaskan Huskies will reliably determine whether a dog is a genetic Carrier of Alaskan Husky encephalopathy.  Alaskan Husky encephalopathy is inherited in an Autosomal Recessive manner in dogs meaning that they must receive two copies of the mutated gene (one from each parent) to develop the disease.  In general, carrier dogs do not have features of the disease but when bred with another carrier of the same Mutation, there is a risk of having affected pups.  Each pup that is born to this pairing has a 25% chance of inheriting the disease and a 50% chance of inheriting one copy and being a carrier of the SLC19A3 gene mutation.  Reliable genetic testing is important for determining breeding practices.  In order to eliminate this mutation from breeding lines and to avoid the potential of producing affected pups, breeding of known carriers to each other is not recommended.  Alaskan Huskies that are not carriers of the mutation have no increased risk of having affected pups.


There may be other causes of this condition in dogs and a normal result does not exclude a different mutation in this gene or any other gene that may result in a similar genetic disease or trait.
 

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  • Home
  • About
    • Club Ethos
    • Club Code of Ethics
    • Club Dog Working, Showing & Pack Walks
    • Club Membership
    • Club Merchandise >
      • Pyrography
      • Car Decals
      • Clothing >
        • Size & Colour Chart
      • Custom Embroidery Designs
      • Dog Accessories
      • Keyrings
      • Miscellaneous
    • Meet the Pack & Club Event Photos
    • Rainbow Bridge
  • Education & Public Speaking
  • Contact
  • Ain't Nothing But A Hound Day
    • Gleblands Park - Newport
    • Victoria Park - Cardiff
    • Romilly Park - Barry
    • Roath Recreation Ground - Cardiff
  • Dog Show Sponsors 2019
  • Canine First Aid & Health & Wellbeing
    • Canine First Aid Kit Contents
    • Bandaging & Wound Cleaning
    • Emergency First Aid A - E >
      • Abscesses
      • Adder Snake Bite
      • Bee Stings & Insect Bites
      • Bleeding (external)
      • Bleeding (internal)
      • Bloat
      • Chemical Burns
      • Choking
      • CPR - Cardio Pulmonary Resusitation
      • Dehydration
      • Dental Emergencies
      • Difficult Births
      • Drowning
      • Eye Injuries
    • Emergency First Aid E - O >
      • Electrocution
      • Fainting - "Syncope"
      • False Widow Spider Bite
      • Fever
      • Fox Bites
      • Fractures
      • Heatstroke
      • Hot Spots - Canine Acute Moist Dermatitis
      • Hypothermia
      • Nose Bleed
    • Emergency First Aid P - Z >
      • Paralysis
      • Poisoning and Exposure to Toxins
      • Penetrating Injuries
      • Rat Bites
      • Seizures
      • Shock
      • Straining & Constipation
      • Transporting Injurerd Dogs
    • Health & Wellbeing >
      • Health Conditions A - E >
        • Abnormal Heart Rhythm in Dogs
        • Alaskan Husky Encephalopathy (Sub acute Necrotizing Encephalomyelopathy)
        • B12 Deficiency or Cobalamin Malabsorption
        • Breathing Difficulties
        • Canine Athletes Heart Syndrome
        • Congenital Heart Disease in Dogs
        • Epilepsy
      • Health Conditions F -M >
        • Hip dysplasia
        • Hypoglycemia
        • Hypothyroidism & Hyperthyroidism
        • Joint Luxation
        • Ligament and Tendon Tears
        • Metabolic Myopathy
      • Health Conditions N - Z >
        • Paw Pad Problems
        • Portal Systemic Shunts
        • Pyometra & Cystic Endometrial Hyperplasia
        • Snow Nose
        • Stomach Ulcers
        • Tendonitis
        • Urinary Tract Health
      • Infectious diseases >
        • Alabama Rot
        • Cryptococcosis
        • Distemper
        • Erlichiosis
        • Hepatitis
        • Histoplasmosis
        • Parvovirus
        • Rabies
      • Welbeing A - G >
        • Anal Glands/Sacks
        • Burns
        • Coconut Oil
        • Dry Dog Food
        • Grooming and maintenance
      • Wellbeing H - Z >
        • Heat Stroke
        • How To Trim Your Dogs Claws
        • Raw Feeding
        • Toxic Food - Fruits, vegtables & Fish
        • Turmeric Powder
        • Vitaimin E
        • Zinc Deficency
      • Dental Care
      • Nutrition
      • Vaccinations, Worming, Microchipping >
        • Kennel Cough
        • Microchipping
        • Vaccinaions
        • Worming, Flea & Tick Prevention & Parasites
      • Spaying & Neutering
      • Veterinary Clinical Examination
  • Controlling Your Dog In Public
    • Banned Breeds
    • Dangerous Dog Act 2017
    • Dog fouling
    • Public Spaces Protection Orders
  • Donation & Fundraising
  • Easy Fundraising
  • Evolution Of Dogs
    • Breeds >
      • Spitz Breeds >
        • Alaskan Husky
        • Aalaskan Klee Kai
        • Alaskan Malamute
        • Chow Chow
        • Crossd Breed - Huskamute
        • Greenland Dogs
        • Japanese Akita Inu & American Akita
        • Samoyed
        • Siberian Husky
        • Tamaskan
      • Wolf Hybrids >
        • Czechoslovakian wolf dog
        • Saarlooswolfhond
        • Timberwolfdog
  • Equipment
    • Collars
    • Cooling Coats & Mats
    • Scooters, Dry Land Rig and Sleds
    • Walking Belt
    • Dog Weather Shelter
    • Head Collar
    • Leads
    • Harnesses
    • Stake out lines
  • Puppy and dog walking tips
  • Training
    • Canicross
    • Crate Training
    • Obedience training >
      • Bite Inhibition
      • Leave it Training
      • Recall Training
      • Sit Training
      • Sit & Stay Training
      • Walking to Heel Training
    • Temperature Guide to Safely Work Your Dog
    • Toilet Training
    • Vocal Commands
    • Weight Pull Training
    • Working In Racing Harness Sled/Dry Land Rig or Scooter